Amelogenins are the main proteins of the forming enamel extracellular matrix proteins (EMPs). Ameloginin's hydrophobic molecules self-assemble into nanospheric structures, which regulate the oriented and elongated growth, shape, and size of the enamel mineral crystal. They influence the arrangement of the 3D structure of ligaments’ collagen type I, proteoglycans, and chondrocytes and are all key players in cartilage regeneration.
Amelogenins recruit mesenchymal stem cells (MSC) and pericytes to the injured site which subsequently differentiate to regenerate the affected tissues.
The product serves as a physical scaffold with a biologically active component: The human recombinant amelogenin nanospheres play an
extra-cellular structural role in the development of various tissues.